Valencia would be looking to get to the final of this competition by winning this game. They have all the advantages after they came from 2 goals down to secure a 2-2 draw in the first leg.
The home side also come into this game on a rich run of form that has seen them remain unbeaten in their last 9 games in all competitions including beating Celtic home and away in the Europa League.
They drew their last game against Leganes in an unlucky manner as they had been winning until the dying moments when the home side found an equalizer.
Real Betis would curse their luck after they failed to win the first leg despite being 2-0 for much of the game. They now have to win here to progress.
The visitors are not in the best of shapes as they have won just one of their last six matches and that win came in their last league game against Valladolid.