Liverpool would be looking to avoid starting Thursday in the Europa League as it would affect their bid to win the Premier League title this season.
The Reds however, have a major job to do in terms of becoming the first team to beat Napoli in the Champions League this season.
They come into this game in fine form domestically, they beat Burnley 3-1 and Bournemouth 4-0 away from home in their last two games.
They would be without Joe Gomez for this game, but the presence of their feared front three and the noise from Anfield should help them get a win here by keeping a clear sheet or scoring the needed two clear goals.
Napoli have continued to grow despite losing Maurizio Sarri in the summer. The Italians currently top this group as they have remained unbeaten in the Champions League so far.
They simply need to avoid defeat by two clear goals and they would qualify for the next round. If they are beaten by Liverpool, then they would need a helping hand from Red Star in Serbia to advance.