This game offers Manchester City the chance to avenge their shocking 3-2 loss to Palace just before Christmas but a defeat here or dropped points would put Liverpool in the driving seat in the race for the title.
Manchester City suffered just their second loss of the year when they were beaten 1-0 by Tottenham in the Champions League on Tuesday.
The Cityzens usually bounce back quickly and they could do so here as Crystal have the third worse home record in the Premier League this season.
The Eagles do well away from home but not so good at Selhurst Park. However, they held Manchester City to a goalless draw and nearly beat them the last time the defending champions visited them.
The Cityzens are still very much in the race for five trophies as their manager has claimed and a win here could see them return to the top of the league table with a game in had if Chelsea takes some points off Liverpool.